Efeito da administração de insulina oral no epitélio de ratos hiperglicêmicos

Abstract

The chronic disease characterized by hyperglycemia, diabetes, has become a global health problem, the habits of the population in recent decades have contributed a lot to the current reality. This disease has been challenging scientists to find new methods of more efficient treatments and that bring better adherence to these chronic patients, without the side effects presented today. Many types of research are being conducted to arrive at a formula that has greater bioavailability in the digestive tract. This study aims to evaluate the effect of treatment with oral insulin nanocapsules in hyperglycemic rats. Methods: Male Wistar rats, aged between 2 and 3 months, with the average weight of 300g, divided into 4 groups of 15 animals each, all received a conventional diet ad libitum, and hyperglycemia was induced through the administration of streptozotocin. The present study demonstrated that oral insulin administered through nanocapsules contributed to the decrease in serum triglyceride levels in hyperglycemic animals (p<0.05), also found a significant hypoglycemic effect in relation to those who received only the nanocapsules (p<0.05), in addition, were observed significant changes in the intestinal epithelium. Despite the findings in this study, more research is necessary to understand the effects of oral insulin on the intestinal epithelium.