Influência do ibuprofeno sobre a concentração plasmática e tecidual da amoxicilina em ratos com lesão periapical induzida

Abstract

The prescription of anti-inflammatories and antibiotics is a common practice in dentistry. Drug interactions can occur when medicines are administered at the same time. The objective of this present research was to evaluate the influence of ibuprofen on plasma and periapical tissue amoxycillin concentration in induced apical periodontitis in rats. 28 Wistar male rats (45 days) were divided into 4 groups: PL: placebo (saline); AM: amoxycillin (100 mg / kg); IB ibuprofen (100 mg / kg); and AM+IB amoxycillin (100 mg / kg) + ibuprofen (100 mg / kg). The animals were submitted to pulp exposure in the first lower left molar, which remained open for 15 days and then closed with composite resin, maintained for more 07 days. The rats were treated with a single dose (gavage) according to each group, 01 hour before euthanasia.Two milliliters of blood was collected from the aorta to obtain blood plasma samples and the periapical tissue were homogenised to obtain the supernatant. From the samples (plasma and the supernatant periapical tissue) was carried out antibiogram for analysis of plasma and tissue amoxycillin levels. Results showed that AM group showed plasma higher amoxycillin concentrations than the other groups (p <0.05, ANOVA with Tukey). Ibuprofen interferes with the amoxycillin plasma concentration, however, AM+IB group had a higher amoxycillin concentration than the PL and IB groups (p<0.05, ANOVA with Tukey test). The analysis of the periapical tissue supernatant showed no significant difference among groups (p> 0.05, Kruskal-Wallis). In conclusion, ibuprofen can interfere with amoxycillin plasm concentration, but had noinfluence on amoxycillin periapical tissue concentration.