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Title:
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A quantitative validated method using liquid chromatography and chemometric analysis for evaluation of raw material of Maytenus ilicifolia (SCHRAD.) PLANCH., CELASTRACEAE |
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Author:
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Beltrame, Flávio Luís; Mainardes, Rubiana Mara; Khalil, Najeh Maissar; Prestes, Rosilene Aparecida; Nogueira, Alessandro; Demiate, Ivo Mottin; Cass, Quezia Bezerra
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Abstract:
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The hydroalcoholic extracts prepared from standard leaves of Maytenus ilicifolia and commercial samples of espinheira-santa were evaluated qualitatively (fingerprinting) and quantitatively. In this paper, fingerprinting chromatogram coupled with Principal Component Analysis (PCA) is described for the metabolomic analysis of standard and commercial espinheira-santa samples. The epicatechin standard was used as an external standard for the development and validation of a quantitative method for the analysis in herbal medicines using a photo diode array detector. This method has been applied for quantification of epicatechin in commercialized herbal medicines sold as espinheira-santa in Brazil and in the standard sample of M. ilicifolia. |
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URI:
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http://ri.uepg.br:8080/riuepg//handle/123456789/819
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Date:
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2012 |